Jason is interested in how individual relationships between cells, proteins, and biophysical factors impact higher-order features of lung tissue.
In his academic career, Jason plans to develop a laboratory at the intersection of biomaterials, spatial biology, and bioinformatics. His future laboratory will utilize bioengineering principles to model and answer systems-level questions about lung disease. While Jason is primarily interested in studying neighborhood-based interactions in pulmonary tissue, but aspires to develop platforms that are applicable to multiple organ systems.
As an Instructor (previously postdoctoral fellow) in the Longaker Lab, Jason investigates the fundamental biological mechanisms that drive fibrosis vs. regeneration of lungs and other organs using spatial biology, bioinformatics, and machine learning-based image analysis.
As a graduate student in the Mikos Lab, Jason developed click functionalized polymers for modular spatial patterning of biochemical cues for tissue regeneration. He applied these polymers for the fabrication of injectable hydrogels and 3D printable scaffolds.
Jason L. Guo, Ph.D. 